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KMID : 0350519950480030777
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Journal of Catholic Medical College
1995 Volume.48 No. 3 p.777 ~ p.788
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Expression of the Estrogen Receptor Gene in Breast Cancer
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서영진 정상설
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Abstract
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The initiation and progression of breast carcinoma are heavily influenced by hormonal factors. Breast tumors that express the estrogen receptor (ER) are slower growing, associated with longterm disease-free survival, and amenable to endocrine
therpy
with agents such as the antiestrogen. But only 60% of the ER-positive breast cancer patients respond to endocrine manipulation. In addition, many cases of ER-positive cancer that initially respond to endocrine therapy ultimately progress to a
more
aggressive hormone-independent phenotype.
Loss of estrogen receptor expression is an important means of hormone resistance, but the mechanisms involved are not fully understood.
The authors examined the ER by dextran-coated charcoal assay and the ER cDNA by reverse transcription-polymerase chain reaction in 19 cases of primary breast cancer to determine if alterations of the gene are associated with the ER-negative
status.
From this study, the authors were able to see the expression of the ER gene in all of the ER- positive specimens, but the ER-negative group showed inconsistent esults. Four out of 9 ER-negative specimens expressed the ER gene. Three of these four
were
progesterone receptor-positive. This results suggest that ER expression may be determined at the transcription level and that genomic analysis of the ER may be more accurate than conventional ER assays in clinical settings.
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KEYWORD
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